I did lot of research on this topic, when I open PowerPoint by default its open with title and subtitle text box in slide layout, but I want to set it as a blank slide, I tried many things none of work perfectly, lastly I found a best idea to open PowerPoint as blank slide each time when open. This method will work all the version of PowerPoint like 2003, 2007, 2010, 2016, so lets see how to do this..
1. Open PowerPoint right click on slide click on “Layout” and select “Blank”
2. Now press “Ctrl+S” give the file name, in save as type select “PowerPoint Template” select desktop as output location and “save” the file.
3. Now close this PowerPoint file, you will find a ppt file on desktop open that file, this is a ppt template, this file will open as blank slide layout each when you open.